What is the correct method for handling newborn screening specimens?

In newborn screening, it is crucial to ensure that the specimens are collected and handled properly to maintain their integrity for accurate testing. The recommended method involves using one free-flowing drop of blood to fill both sides of the filter paper. This technique is designed to promote even distribution of the blood, which is essential for obtaining reliable screening results. After applying the drops, the specimens should be air-dried completely in a flat and elevated position. This drying process helps prevent hemolysis or contamination that can occur if the sample is stacked or improperly stored, ensuring that the sample remains viable for testing.

The importance of air-drying is particularly significant in newborn screening to preserve the characteristics of the sample and prevent degradation. Once dried, the samples can then be prepared for transport without the risks associated with improper handling. This method has been established through guidelines to optimize the testing process for conditions like phenylketonuria (PKU) and other metabolic disorders.